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Diagnosis of glaucoma by indirect classifiers

Peters, A and Lausen, B and Michelson, G and Gefeller, O (2003) 'Diagnosis of glaucoma by indirect classifiers.' Methods of Information in Medicine, 42 (1). 99 - 103. ISSN 0026-1270

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Abstract

Objectives: Demonstration of the applicability of a framework called indirect classification to the example of glaucoma classification. Indirect classification combines medical a priori knowledge and statistical classification methods. The method is compared to direct classification approaches with respect to the estimated misclassification error. Methods: Indirect classification is applied using classification trees and the diagnosis of glaucoma. Misclassification errors are reduced by bootstrap aggregation. As direct classification methods linear discriminant analysis, classification trees and bootstrap aggregated classification trees are utilized in the problem of glaucoma diagnosis. Misclassification rates are estimated via 10-fold cross-validation. Results: Indirect classification techniques reduce the misclassification error in the context of glaucoma classification compared to direct classification methods. Conclusions: Embedding a priori knowledge into statistical classification techniques can improve misclassification results. Indirect classification offers a framework to realize this combination.

Item Type: Article
Subjects: H Social Sciences > HA Statistics
R Medicine > RE Ophthalmology
Divisions: Faculty of Science and Health > Mathematical Sciences, Department of
Depositing User: Berthold Lausen
Date Deposited: 04 Jul 2012 21:41
Last Modified: 17 Aug 2017 18:12
URI: http://repository.essex.ac.uk/id/eprint/2497

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