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Urinary calcium excretion in healthy children and adolescents

Manz, F and Kehrt, R and Lausen, B and Merkel, A (1999) 'Urinary calcium excretion in healthy children and adolescents.' Pediatric Nephrology, 13 (9). 894 - 899. ISSN 0931-041X

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Urinary calcium (Ca) excretion was determined in 1578 24-h urine samples from 507 healthy children and adolescents (252 boys, 255 girls; 2.8-18.4 years) participating in the DONALD Study and is presented for 32 different age and sex groups. Calciuria values related to body weight (mg/kg per day) were relatively constant except for a transient decrease during puberty in all centiles, with a later onset in boys than girls. Distribution of calciuria (mg/kg per day) was best normalized by log transformation, with an almost constant standard deviation of the log-transformed values. Ca excretion was ≥ 4 mg/kg per day in 8.6% and ≥ 6 mg/kg per day in 1.5% of the urine samples. Based on Ca excretion rates of 1080 pairs of 24-h urine samples from 364 children and adolescents, sensitivity, specificity, and the predictive value for hypercalciuria (≥ 4 mg/kg per day) in the next urine sample were calculated at three test levels classifying calciuria of the initial urine sample. In summary, this study presents normal values of urinary Ca excretion related to age and sex in a population of healthy German children and adolescents consuming a typical western-style diet. A high level of calciuria in a random urine sample is important in the diagnosis of hypercalciuria.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science and Health > Mathematical Sciences, Department of
Depositing User: Berthold Lausen
Date Deposited: 04 Jul 2012 12:26
Last Modified: 30 Jan 2019 16:21

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