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The role of cluster of differentiation 74 in cancer and cancer immunomodulation

Al Ssadh, Hassan and Alabdulmonem, Waleed and Fernández, Nelson (2019) 'The role of cluster of differentiation 74 in cancer and cancer immunomodulation.' Scientific Journal of King Faisal University (Basic and Applied Sciences), 20 (1). pp. 99-109. ISSN 1658-0311

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In normal cells cluster of differentiation 74 (CD74) acts as a chaperone of human leukocyte antigen (HLA)-DR by formation of a trimetric structure. In the lack of tumor presence most antigen presenting cells are expressed. However, recent data suggests that CD74 is major link between proinflammatory responses and tumorigenesis but that detailed mechanisms are not fully understood. CD74 is also thought to be involved in signalling pathways via macrophage migration inhibitory factor (MIF) and CD44; controlling the proliferation and apoptosis of cancer its capability to interact with other signaling cells. The role CD74 as an accessory signal receptor on surface and molecules presents CD74 as a crucial therapeutic target for the treatment of cancer. This review will discuss the role of CD74 in several aspects including antigen presentation, cancer immunomodulation as well as the interaction of CD74 along with MIF and CD44. The overall aim of this review is to translate the recent outcome from the previous study to the clinical level and to study the expression and the role of CD74 in human breast cancer in Saudi population. Comparison between normal people and patients could be applied. We are also planning to link the level of CD74 expression to different stage of breast cancer so CD74 could potentially be used as a 'biomarker signature' to monitor different stages of breast cancer.

Item Type: Article
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 05 Sep 2019 15:34
Last Modified: 06 Jan 2022 14:04

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