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A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier

Kafash Hoshiar, Ali and Le, Tuan-Anh and Ul Amin, Faiz and Kim, Myeong and Yoon, Jungwon (2018) 'A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier.' Nanomaterials, 8 (1). ISSN 2079-4991

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Abstract

The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed actuation schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel scheme with an aggregation model for a feed-forward magnetic actuation design. A simulation platform for aggregated particle delivery is developed and an actuation scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic actuation. The experimental results with a Y-shaped channel indicated the success of the proposed scheme in steering and disaggregation. The delivery performance of the developed scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed scheme enhanced the transport and uptake of MNPs across the BBB in mice. The scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic actuation scheme.

Item Type: Article
Uncontrolled Keywords: asymmetrical discontinuous field function; blood–brain barrier (BBB); magnetic drug delivery; magnetic nanoparticles; aggregation
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Elements
Date Deposited: 13 Feb 2020 10:04
Last Modified: 13 Feb 2020 10:15
URI: http://repository.essex.ac.uk/id/eprint/25510

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