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Studies of aggregated nanoparticles steering during magnetic-guided drug delivery in the blood vessels

Kafash Hoshiar, Ali and Le, Tuan-Anh and Amin, Faiz Ul and Kim, Myeong Ok and Yoon, Jungwon (2017) 'Studies of aggregated nanoparticles steering during magnetic-guided drug delivery in the blood vessels.' Journal of Magnetism and Magnetic Materials, 427. 181 - 187. ISSN 0304-8853

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Abstract

Magnetic-guided targeted drug delivery (TDD) systems can enhance the treatment of diverse diseases. Despite the potential and promising results of nanoparticles, aggregation prevents precise particle guidance in the vasculature. In this study, we developed a simulation platform to investigate aggregation during steering of nanoparticles using a magnetic field function. The magnetic field function (MFF) comprises a positive and negative pulsed magnetic field generated by electromagnetic coils, which prevents adherence of particles to the vessel wall during magnetic guidance. A commonly used Y-shaped vessel was simulated and the performance of the MFF analyzed; the experimental data were in agreement with the simulation results. Moreover, the effects of various parameters on magnetic guidance were evaluated and the most influential identified. The simulation results presented herein will facilitate more precise guidance of nanoparticles in vivo.

Item Type: Article
Uncontrolled Keywords: Targeted drug delivery (TDD), Nanorobotic, Aggregation, Magnetic Nanoparticles
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Elements
Date Deposited: 13 Feb 2020 10:23
Last Modified: 13 Feb 2020 11:15
URI: http://repository.essex.ac.uk/id/eprint/25512

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