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Double-blind placebo-controlled trial of quetiapine in anorexia nervosa

Powers, Pauline S and Klabunde, Megan and Kaye, Walter (2012) 'Double-blind placebo-controlled trial of quetiapine in anorexia nervosa.' European Eating Disorders Review, 20 (4). 331 - 334. ISSN 1072-4133

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Abstract

Objective Our objective is to determine whether quetiapine was superior to placebo in increasing weight or reducing core symptoms of anorexia nervosa as assessed by the Yale-Brown-Cornell Eating Disorder Scale and the Eating Disorder Inventory-2. Method Participants were randomised to 8 weeks of quetiapine or placebo. Results There are 21 participants who signed informed consent, 15 were randomised, 14 returned for at least one visit after receiving drug and 10 completed the study. There were no differences between drug and placebo in questionnaire scores, weight or measures of anxiety or depression. Discussion There was no difference between quetiapine and placebo on weight gain or core symptoms. Small effect sizes suggest that a higher number of participants would not increase significant differences between groups. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.

Item Type: Article
Divisions: Faculty of Science and Health > Psychology, Department of
Depositing User: Elements
Date Deposited: 15 Nov 2019 10:20
Last Modified: 15 Nov 2019 10:20
URI: http://repository.essex.ac.uk/id/eprint/25536

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