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The transferability of lipid loci across African, Asian and European cohorts

Kuchenbaecker, K and Telkar, N and Reiker, T and Walters, RG and Lin, K and Eriksson, A and Gurdasani, D and Gilly, A and Southam, L and Tsafantakis, E and Karaleftheri, M and Seeley, J and Kamali, A and Asiki, G and Millwood, IY and Holmes, M and Du, H and Guo, Y and Kumari, M and Dedoussis, G and Li, L and Chen, Z and Sandhu, MS and Zeggini, E and Understanding Society Scientific Group, (2019) 'The transferability of lipid loci across African, Asian and European cohorts.' Nature Communications, 10. ISSN 2041-1723

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Abstract

Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23–0.28, p < 1.9 × 10−14). Overall, there is evidence of reproducibility for ~75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan samples (10% of loci). Individual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions.

Item Type: Article
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Elements
Date Deposited: 28 Nov 2019 10:06
Last Modified: 28 Nov 2019 10:06
URI: http://repository.essex.ac.uk/id/eprint/26036

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