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DNA methylation aging clocks: challenges and recommendations

Bell, Christopher G and Lowe, Robert and Adams, Peter D and Baccarelli, Andrea A and Beck, Stephan and Bell, Jordana T and Christensen, Brock C and Gladyshev, Vadim N and Heijmans, Bastiaan T and Horvath, Steve and Ideker, Trey and Issa, Jean-Pierre J and Kelsey, Karl T and Marioni, Riccardo E and Reik, Wolf and Relton, Caroline L and Schalkwyk, Leonard C and Teschendorff, Andrew E and Wagner, Wolfgang and Zhang, Kang and Rakyan, Vardhman K (2019) 'DNA methylation aging clocks: challenges and recommendations.' Genome Biology, 20 (1). ISSN 1474-7596

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Abstract

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual.

Item Type: Article
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Elements
Date Deposited: 06 Dec 2019 14:09
Last Modified: 06 Dec 2019 14:15
URI: http://repository.essex.ac.uk/id/eprint/26163

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