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PopTargs: a database for studying population evolutionary genetics of human microRNA target sites

Hatlen, Andrea and Helmy, Mohab and Marco, Antonio (2019) 'PopTargs: a database for studying population evolutionary genetics of human microRNA target sites.' Database, 2019 (1). ISSN 1758-0463

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Abstract

There is an increasing interest in the study of polymorphic variants at gene regulatory motifs, including microRNA target sites. Understanding the effects of selective forces at specific microRNA target sites, together with other factors like expression levels or evolutionary conservation, requires the joint study of multiple datasets. We have compiled information from multiple sources and compared it with predicted microRNA target sites to build a comprehensive database for the study of microRNA targets in human populations. PopTargs is a web-based tool that allows the easy extraction of multiple datasets and the joint analyses of them, including allele frequencies, ancestral status, population differentiation statistics and site conservation. The user can also compare the allele frequency spectrum between two groups of target sites and conveniently produce plots. The database can be easily expanded as new data becomes available and the raw database as well as code for creating new custom-made databases is available for downloading. We also describe a few illustrative examples.

Item Type: Article
Uncontrolled Keywords: Alleles; Databases, Nucleic Acid; Gene Frequency; Human Genetics; Humans; Internet; MicroRNAs
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 16 Jul 2021 12:59
Last Modified: 06 Jan 2022 14:06
URI: http://repository.essex.ac.uk/id/eprint/26412

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