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The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth

Gonzalez, Suam and Rallis, Charalampos (2017) 'The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth.' Frontiers in Cell and Developmental Biology, 5 (JUN). 61-. ISSN 2296-634X

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Abstract

Cell size is amenable by genetic and environmental factors. The highly conserved nutrient-responsive Target of Rapamycin (TOR) signaling pathway regulates cellular metabolic status and growth in response to numerous inputs. Timing and duration of TOR pathway activity is pivotal for both cell mass built up as well as cell cycle progression and is controlled and fine-tuned by the abundance and quality of nutrients, hormonal signals, growth factors, stress, and oxygen. TOR kinases function within two functionally and structurally discrete multiprotein complexes, TORC₁ and TORC₂, that are implicated in temporal and spatial control of cell size and growth respectively; however, recent data indicate that such functional distinctions are much more complex. Here, we briefly review roles of the two complexes in cellular growth and cytoarchitecture in various experimental model systems.

Item Type: Article
Uncontrolled Keywords: cell size; cell cycle; growth; rapamycin; signaling; nutrients; TORC1; TORC2
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 18 Jun 2021 15:30
Last Modified: 18 Aug 2022 10:48
URI: http://repository.essex.ac.uk/id/eprint/26694

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