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Isolation of the avian homologue of the homeobox gene Mox2 and analysis of its expression pattern in developing somites and limbs.

Rallis, Charalampos and Stamataki, Despina and Pontikakis, Spyros and Mankoo, Baljnder S and Karagogeos, Domna (2001) 'Isolation of the avian homologue of the homeobox gene Mox2 and analysis of its expression pattern in developing somites and limbs.' Mechanisms of Development, 104 (1-2). pp. 121-124. ISSN 0925-4773

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Abstract

We have isolated the cDNA of avian Mox2 and analyzed its expression pattern during somitogenesis and limb bud formation. Mox2 plays an important role in limb muscle differentiation in the mouse. Mox2 is expressed in the somites of developing chick embryos and in presumptive migrating myoblasts from the dermomyotome to the limb buds. It is also expressed in the ventral and dorsal part of limb buds and is associated with non-proliferating myoblasts. Significant differences were observed in chick and mouse expression patterns, namely in the chick dermomyotome and limb.

Item Type: Article
Uncontrolled Keywords: Extremities; Chick Embryo; Animals; Humans; Mice; Rats; DNA-Binding Proteins; Transcription Factors; DNA, Complementary; Bromodeoxyuridine; Antigens, CD; Antigens, Surface; Immunohistochemistry; In Situ Hybridization; Cloning, Molecular; Amino Acid Sequence; Sequence Homology, Amino Acid; Tissue Distribution; Time Factors; Molecular Sequence Data; Paired Box Transcription Factors; PAX3 Transcription Factor
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 18 Jun 2021 11:44
Last Modified: 06 Jan 2022 14:10
URI: http://repository.essex.ac.uk/id/eprint/26735

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