Research Repository

Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

Dong, Yue and Lin, Hungyen and Abolghasemi, Vahid and Gan, Lu and Zeitler, J Axel and Shen, Yao-Chun (2017) 'Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography.' Journal of Pharmaceutical Sciences, 106 (2). pp. 546-553. ISSN 0022-3549

PIIS0022354916417508.pdf - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview


Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating uniformity without compromising on the achievable axial resolution and imaging depth, we comprehensively examine an algebraic reconstruction technique with OCT to significantly reduce the data required. Specifically, a set of coated pharmaceutical tablets with film coating thickness in the range of 60-100 μm is investigated. Results obtained from performing the reconstruction reveal that only 30% of the acquired data are actually required leading to a faster convergence time and a generally good agreement with benchmark data against the intra-tablet coating uniformity measured with terahertz pulsed imaging technology.

Item Type: Article
Uncontrolled Keywords: coating; optical coherence tomography; imaging method; process analytical technology; tablet
Divisions: Faculty of Science and Health
Faculty of Science and Health > Computer Science and Electronic Engineering, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 23 Apr 2020 13:36
Last Modified: 23 Sep 2022 19:33

Actions (login required)

View Item View Item