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Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

Dong, Yue and Lin, Hungyen and Abolghasemi, Vahid and Gan, Lu and Zeitler, J Axel and Shen, Yao-Chun (2017) 'Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography.' Journal of Pharmaceutical Sciences, 106 (2). 546 - 553. ISSN 0022-3549

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Abstract

Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating uniformity without compromising on the achievable axial resolution and imaging depth, we comprehensively examine an algebraic reconstruction technique with OCT to significantly reduce the data required. Specifically, a set of coated pharmaceutical tablets with film coating thickness in the range of 60-100 μm is investigated. Results obtained from performing the reconstruction reveal that only 30% of the acquired data are actually required leading to a faster convergence time and a generally good agreement with benchmark data against the intra-tablet coating uniformity measured with terahertz pulsed imaging technology.

Item Type: Article
Uncontrolled Keywords: coating, optical coherence tomography, imaging method, process analytical technology, tablet
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Elements
Date Deposited: 23 Apr 2020 13:36
Last Modified: 23 Apr 2020 13:36
URI: http://repository.essex.ac.uk/id/eprint/27071

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