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A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue.

Lee, Seungmin and Kim, Jin-Young and Kim, Junyoung and Kafash Hoshiar, Ali and Park, Jongeon and Lee, Sunkey and Kim, Jonghyun and Pané, Salvador and Nelson, Bradley J and Choi, Hongsoo (2020) 'A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue.' Advanced Healthcare Materials, 9 (7). ISSN 2192-2640

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Abstract

A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2 ) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s-1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments.

Item Type: Article
Uncontrolled Keywords: Microrobot; magnetic manipulation; drug delivery; targeted delivery; fixation
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Elements
Date Deposited: 27 Apr 2020 15:24
Last Modified: 03 Mar 2021 02:00
URI: http://repository.essex.ac.uk/id/eprint/27374

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