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To What Extent is Blood a Reasonable Surrogate for Brain in Gene Expression Studies: Estimation from Mouse Hippocampus and Spleen.

Davies, Matthew N and Lawn, Sarah and Whatley, Steven and Fernandes, Cathy and Williams, Robert W and Schalkwyk, Leonard C (2009) 'To What Extent is Blood a Reasonable Surrogate for Brain in Gene Expression Studies: Estimation from Mouse Hippocampus and Spleen.' Frontiers in Neuroscience, 3. ISSN 1662-453X

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Abstract

Microarrays are designed to measure genome-wide differences in gene expression. In cases where a tissue is not accessible for analysis (e.g. human brain), it is of interest to determine whether a second, accessible tissue could be used as a surrogate for transcription profiling. Surrogacy has applications in the study of behavioural and neurodegenerative disorders. Comparison between hippocampus and spleen mRNA obtained from a mouse recombinant inbred panel indicates a high degree of correlation between the tissues for genes that display a high heritability of expression level. This correlation is not limited to apparent expression differences caused by sequence polymorphisms in the target sequences and includes both cis and trans genetic effects. A tissue such as blood could therefore give surrogate information on expression in brain for a subset of genes, in particular those co-expressed between the two tissues, which have heritably varying expression.

Item Type: Article
Uncontrolled Keywords: hippocampus, spleen, recombinant inbred strain, gene expression, surrogacy
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Elements
Date Deposited: 13 May 2020 14:13
Last Modified: 13 May 2020 15:15
URI: http://repository.essex.ac.uk/id/eprint/27505

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