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Symptoms of depersonalisation/derealisation disorder as measured by brain electrical activity: A systematic review

Salami, Abbas and Andreu-Perez, Javier and Gillmeister, Helge (2020) 'Symptoms of depersonalisation/derealisation disorder as measured by brain electrical activity: A systematic review.' Neuroscience and Biobehavioral Reviews, 118. 524 - 537. ISSN 0149-7634

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Depersonalisation/derealisation disorder (DPD) refers to frequent and persistent detachment from bodily self and disengagement from the outside world. As a dissociative disorder, DPD affects 1–2 % of the population, but takes 7–12 years on average to be accurately diagnosed. In this systematic review, we comprehensively describe research targeting the neural correlates of core DPD symptoms, covering publications between 1992 and 2020 that have used electrophysiological techniques. The aim was to investigate the diagnostic potential of these relatively inexpensive and convenient neuroimaging tools. We review the EEG power spectrum, components of the event-related potential (ERP), as well as vestibular and heartbeat evoked potentials as likely electrophysiological biomarkers to study DPD symptoms. We argue that acute anxiety- or trauma-related impairments in the integration of interoceptive and exteroceptive signals play a key role in the formation of DPD symptoms, and that future research needs analysis methods that can take this integration into account. We suggest tools for prospective studies of electrophysiological DPD biomarkers, which are urgently needed to fully develop their diagnostic potential.

Item Type: Article
Uncontrolled Keywords: Depersonalisation, Derealisation, EEG, ERPs, Biomarkers
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Faculty of Science and Health > Psychology, Department of
Depositing User: Elements
Date Deposited: 23 Sep 2020 15:39
Last Modified: 25 Aug 2021 01:00

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