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The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire

Edwards, Marcus J and White, Gaye F and Butt, Julea N and Richardson, David J and Clarke, Thomas A (2020) 'The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire.' Cell, 181 (3). 665-673.e10. ISSN 0092-8674

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A growing number of bacteria are recognized to conduct electrons across their cell envelope, and yet molecular details of the mechanisms supporting this process remain unknown. Here, we report the atomic structure of an outer membrane spanning protein complex, MtrAB, that is representative of a protein family known to transport electrons between the interior and exterior environments of phylogenetically and metabolically diverse microorganisms. The structure is revealed as a naturally insulated biomolecular wire possessing a 10-heme cytochrome, MtrA, insulated from the membrane lipidic environment by embedding within a 26 strand β-barrel formed by MtrB. MtrAB forms an intimate connection with an extracellular 10-heme cytochrome, MtrC, which presents its hemes across a large surface area for electrical contact with extracellular redox partners, including transition metals and electrodes.

Item Type: Article
Uncontrolled Keywords: extracellular electron transfer; shewanella; porin-cytochrome complex; iron oxidation; metal reduction; respiration; outer membrane protein; electrogenic bacteria; geobacter; decaheme
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 07 Oct 2020 15:11
Last Modified: 18 Aug 2022 10:48

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