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Manganese-enhanced Magnetic Resonance Imaging in Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy.

Spath, Nick and Singh, Trish and Papanastasiou, Giorgos and Kershaw, Lucy and Baker, Andrew and Janisczek, Rob and Gulsin, Gaurav and Dweck, Marc and McCann, Gerry and Newby, David and Semple, Scott (2020) 'Manganese-enhanced Magnetic Resonance Imaging in Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy.' European Heart Journal - Cardiovascular Imaging. ISSN 2047-2412

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Patients with dilated cardiomyopathy (n= 10) or hypertrophic cardiomyopathy (n= 17) underwent both gadoliniumand manganese contrast-enhanced magnetic resonance imaging and were compared with healthy volunteers(n= 20). Differential manganese uptake (Ki) was assessed using a two-compartment Patlak model. Compared withhealthy volunteers, reduction in T1 with manganese-enhanced magnetic resonance imaging was lower in patientswith dilated cardiomyopathy [mean reduction 257 ± 45 (21%) vs. 288 ± 34 (26%) ms,P< 0.001], with higher T1 at40 min (948 ± 57 vs. 834 ± 28 ms,P< 0.0001). In patients with hypertrophic cardiomyopathy, reductions in T1 wereless than healthy volunteers [mean reduction 251 ± 86 (18%) and 277 ± 34 (23%) vs. 288 ± 34 (26%) ms, with andwithout fibrosis respectively,P< 0.001]. Myocardial manganese uptake was modelled, rate of uptake was reducedin both dilated and hypertrophic cardiomyopathy in comparison with healthy volunteers (meanKi19 ± 4, 19 ± 3,and 23 ± 4 mL/100 g/min, respectively;P= 0.0068). In patients with dilated cardiomyopathy, manganese uptake ratecorrelated with left ventricular ejection fraction (r2= 0.61,P= 0.009). Rate of myocardial manganese uptake demon-strated stepwise reductions across healthy myocardium, hypertrophic cardiomyopathy without fibrosis and hyper-trophic cardiomyopathy with fibrosis providing absolute discrimination between the healthy myocardium andfibrosed myocardium (meanKi23 ± 4, 19 ± 3, and 13 ± 4 mL/100 g/min, respectively;P< 0.0001).

Item Type: Article
Uncontrolled Keywords: manganese-enhanced magnetic resonance imaging, MEMRI, non-ischaemic cardiomyopathy
Divisions: Faculty of Science and Health
Faculty of Science and Health > Computer Science and Electronic Engineering, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 24 Nov 2020 11:00
Last Modified: 06 Jan 2022 14:18

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