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Dopaminergic and opioidergic regulation during anticipation and consumption of social and nonsocial rewards

Korb, Sebastian and Götzendorfer, Sebastian J and Massaccesi, Claudia and Sezen, Patrick and Graf, Irene and Willeit, Matthäus and Eisenegger, Christoph and Silani, Giorgia (2020) 'Dopaminergic and opioidergic regulation during anticipation and consumption of social and nonsocial rewards.' eLife, 9. ISSN 2050-084X

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Abstract

The observation of animal orofacial and behavioral reactions has played a fundamental role in research on reward but is seldom assessed in humans. Healthy volunteers (N = 131) received 400 mg of the dopaminergic antagonist amisulpride, 50 mg of the opioidergic antagonist naltrexone, or placebo. Subjective ratings, physical effort, and facial reactions to matched primary social (affective touch) and nonsocial (food) rewards were assessed. Both drugs resulted in lower physical effort and greater negative facial reactions during reward anticipation, especially of food rewards. Only opioidergic manipulation through naltrexone led to a reduction in positive facial reactions to liked rewards during reward consumption. Subjective ratings of wanting and liking were not modulated by either drug. Results suggest that facial reactions during anticipated and experienced pleasure rely on partly different neurochemical systems, and also that the neurochemical bases for food and touch rewards are not identical.

Item Type: Article
Divisions: Faculty of Science and Health > Psychology, Department of
Depositing User: Elements
Date Deposited: 14 Oct 2020 12:08
Last Modified: 14 Oct 2020 12:08
URI: http://repository.essex.ac.uk/id/eprint/28894

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