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Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.

Giotis, Efstathios S and Carnell, George and Young, Erik F and Ghanny, Saleena and Soteropoulos, Patricia and Wang, Lin-Fa and Barclay, Wendy S and Skinner, Michael A and Temperton, Nigel (2019) 'Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.' Nature Microbiology, 4 (12). 2035 - 2038. ISSN 2058-5276

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Abstract

Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.

Item Type: Article
Uncontrolled Keywords: Animals, Dogs, Chiroptera, Humans, Orthomyxoviridae, Zoonoses, Receptors, Virus, HLA-DR Antigens, Microarray Analysis, Virus Internalization, Viral Tropism, HEK293 Cells, Madin Darby Canine Kidney Cells
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Elements
Date Deposited: 04 Jan 2021 14:19
Last Modified: 04 Jan 2021 15:15
URI: http://repository.essex.ac.uk/id/eprint/29421

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