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Electron transfer from haem to the di‐iron ferroxidase centre in bacterioferritin

Svistunenko, Dimitri A and Pullin, Jacob and Bradley, Justin and Moore, Geoffrey and Le Brun, Nick and Wilson, Michael (2021) 'Electron transfer from haem to the di‐iron ferroxidase centre in bacterioferritin.' Angewandte Chemie International Edition, 60 (15). pp. 8376-8379. ISSN 1433-7851

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The iron redox cycle in ferritins is not completely understood. Bacterioferritins are distinct from other ferritins in that they contain haem groups. It is acknowledged that the two iron motifs in bacterioferritins, the di‐nuclear ferroxidase centre and the haem B group, play key roles in two opposing processes, iron sequestration and iron mobilisation , respectively, and the two redox processes are independent. Here we show that in Escherichia coli bacterioferritin, there is an electron transfer pathway from the haem to the ferroxidase centre suggesting a new role(s) haem might play in bacterioferritins.

Item Type: Article
Uncontrolled Keywords: electron transfer; ferritins; ferroxidase centre; metalloproteins; stopped-flow spectrophotometry
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 21 Jan 2021 10:59
Last Modified: 06 Jan 2022 14:21

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