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Dietary intake of vitamin A, lung function, and incident asthma in childhood.

Talaei, Mohammad and Hughes, David A and Mahmoud, Osama and Emmett, Pauline M and Granell, Raquel and Guerra, Stefano and Shaheen, Seif O (2021) 'Dietary intake of vitamin A, lung function, and incident asthma in childhood.' European Respiratory Journal. ISSN 0903-1936

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Abstract

Longitudinal epidemiological data are scarce on the relation between dietary intake of vitamin A and respiratory outcomes in childhood. We investigated whether a higher intake of preformed vitamin A or provitamin β-carotene in mid-childhood is associated with higher lung function and with asthma risk in adolescence.In the Avon Longitudinal Study of Parents and Children, dietary intakes of preformed vitamin A and β-carotene equivalents were estimated by food frequency questionnaire at 7 years of age. Post- bronchodilator forced expiratory volume in 1 s (FEV<sub>1</sub>), forced vital capacity (FVC), and forced expiratory flow at 25-75% of FVC (FEF<sub>25-75</sub>) were measured at 15.5 years and transformed to z scores. Incident asthma was defined by new cases of doctor-diagnosed asthma at age 11 or 14 years.In multivariable adjusted models, a higher intake of preformed vitamin A was associated with higher lung function and a lower risk of incident asthma: comparing top <i>versus</i> bottom quartiles of intake, regression coefficients (95% confidence intervals) for FEV<sub>1</sub> and FEF<sub>25-75</sub> were, respectively, 0.21 (0.05-0.38; P-trend 0.008) and 0.18 (0.03-0.32; P-trend 0.02); odds ratios (95% confidence intervals) for FEV<sub>1</sub>/FVC ratio below the lower limit of normal and incident asthma were, respectively, 0.49 (0.27-0.90, P-trend 0.04) and 0.68 (0.47, 0.99; P-trend 0.07). In contrast, there was no evidence for association with β-carotene. We also found some evidence for modification of the associations between preformed vitamin A intake and lung function by <i>BCMO1, NCOR2</i> and <i>CC16</i> gene polymorphisms.A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma.

Item Type: Article
Divisions: Faculty of Science and Health > Mathematical Sciences, Department of
Depositing User: Elements
Date Deposited: 13 Sep 2021 11:53
Last Modified: 13 Sep 2021 11:53
URI: http://repository.essex.ac.uk/id/eprint/31078

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