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Repeated Ischemic Preconditioning Effects on Physiological Responses to Hypoxic Exercise

Chopra, Kiran and Jeffries, Owen and Tallent, Jamie and Heffernan, Shane and Kilduff, Liam and Gray, Adrian and Waldron, Mark (2022) 'Repeated Ischemic Preconditioning Effects on Physiological Responses to Hypoxic Exercise.' Aerospace Medicine and Human Performance, 93 (1). pp. 13-21. ISSN 2375-6314 (In Press)

IPC and hypoxia AMHP FINAL.pdf - Accepted Version

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Introduction Repeated ischemic preconditioning (IPC) can improve muscle and pulmonary oxygen on-kinetics, blood flow and exercise efficiency but these effects have not been investigated severe hypoxia. The aim of the current study was to evaluate the effects of 7 d of IPC on resting and exercising muscle and cardio-pulmonary responses to severe hypoxia. Methods Fourteen subjects received either: 1) 7 d of repeated lower-limb occlusion (4 x 5 min, 217±30 mm Hg) at limb occlusive pressure (IPC) or SHAM (4 x 5 min, 20 mm Hg). Subjects were tested for resting limb blood flow (72), relative microvascular deoxyhemoglobin concentration ([HHB]) and pulmonary oxygen (V ̇O2p) responses to steady state and incremental exercise to exhaustion in hypoxia (fractional inspired O2 = 0.103), which was followed by 7 d of IPC or SHAM, and retesting 72 h post intervention. Results There were no effects of IPC on maximal oxygen consumption, time to exhaustion during the incremental test or minute ventilation and arterial oxygen saturation. However, the IPC group had higher delta efficiency based on pooled results and lower steady state delta[HHB] (IPC ~24% vs. SHAM ~6% pre-to-post), as well as slowing the [HHB] time constant (IPC ~26% vs. SHAM ~3% pre-to-post) and reducing the overshoot in [HHB]:V ̇O2 ratio during exercise onset. Conclusions Collectively, these results demonstrate that muscle O2 efficiency and microvascular O2 distribution can be improved by repeated IPC but there are no effects on maximal exercise capacity in a severe hypoxia.

Item Type: Article
Uncontrolled Keywords: conditioning; oxygen kinetics; near-infrared spectroscopy; hypoxic
Divisions: Faculty of Science and Health
Faculty of Science and Health > Sport, Rehabilitation and Exercise Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 03 Dec 2021 12:58
Last Modified: 02 Mar 2022 15:40

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