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Nutrient-Response Pathways in Healthspan and Lifespan Regulation

Dabrowska, Aleksandra and Kumar, Juhi and Rallis, Charalampos (2022) 'Nutrient-Response Pathways in Healthspan and Lifespan Regulation.' Cells, 11 (9). p. 1568. ISSN 2073-4409

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Cellular, small invertebrate and vertebrate models are a driving force in biogerontology studies. Using various models, such as yeasts, appropriate tissue culture cells, Drosophila, the nematode Caenorhabditis elegans and the mouse, has tremendously increased our knowledge around the relationship between diet, nutrient-response signaling pathways and lifespan regulation. In recent years, combinatorial drug treatments combined with mutagenesis, high-throughput screens, as well as multi-omics approaches, have provided unprecedented insights in cellular metabolism, development, differentiation, and aging. Scientists are, therefore, moving towards characterizing the fine architecture and cross-talks of growth and stress pathways towards identifying possible interventions that could lead to healthy aging and the amelioration of age-related diseases in humans. In this short review, we briefly examine recently uncovered knowledge around nutrient-response pathways, such as the Insulin Growth Factor (IGF) and the mechanistic Target of Rapamycin signaling pathways, as well as specific GWAS and some EWAS studies on lifespan and age-related disease that have enhanced our current understanding within the aging and biogerontology fields. We discuss what is learned from the rich and diverse generated data, as well as challenges and next frontiers in these scientific disciplines.

Item Type: Article
Uncontrolled Keywords: Drosophila melanogaster; Caenorhabditis elegans; mouse; yeast; translation; transcriptome; proteome; metabolome; TORC1; IGF-1; GWAS; EWAS
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 20 Jun 2022 15:21
Last Modified: 18 Aug 2022 10:51

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