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Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre

Gao, Lei and ElwellElwell, Clare E and Kohl-Bareis, Matthias and Gramer, Marcus and Cooper, Chris E and Leung, Terence S and Tachtsidis, Ilias (2011) Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre. In: UNSPECIFIED, ? - ?, United States.

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Abstract

Resolving for changes in concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy has generally been based on the assumption that optical scattering and pathlength remain constant. We have used a novel hybrid optical spectrometer that combines multi-distance frequency and broadband systems to investigate the changes in scattering and pathlength during a Valsalva manoeuvre in 8 adult volunteers. Results show a significant increase in the reduced scattering coefficient of 17% at 790nm and 850nm in 4 volunteers during the peak of the Valsalva. However, these scattering changes do not appear to significantly affect the differential pathlength factor and the tissue haemoglobin concentration measurements. © 2011 Springer Science+Business Media, LLC.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Additional Information: Published proceedings: Advances in Experimental Medicine and Biology
Uncontrolled Keywords: Brain; Humans; Hemoglobins; Spectroscopy, Near-Infrared; Valsalva Maneuver; Adult; Female; Male; Young Adult
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 04 Aug 2011 15:27
Last Modified: 15 Jan 2022 00:23
URI: http://repository.essex.ac.uk/id/eprint/373

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