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Approaches in modelling long-term survival: An application to breast cancer

Perperoglou, A and Keramopoullos, A and van Houwelingen, HC (2007) 'Approaches in modelling long-term survival: An application to breast cancer.' Statistics in Medicine, 26 (13). 2666 - 2685. ISSN 0277-6715

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Several modelling techniques have been proposed for non-proportional hazards. In this work we consider different models which can be classified into three wide categories: models with time-varying effects of the covariates; frailty models and cure rate models. We present those different extensions of the proportional hazards model on an application of 2433 breast cancer patients with a long follow-up. We comment on the differences and similarities among the models and evaluate their performance using survival and hazard plots, Brier scores and pseudo-observations. Copyright © 2006 John Wiley & Sons, Ltd.

Item Type: Article
Subjects: Q Science > QA Mathematics
Divisions: Faculty of Science and Health > Mathematical Sciences, Department of
Depositing User: Aris Perperoglou
Date Deposited: 06 Nov 2012 10:44
Last Modified: 23 Jan 2019 05:15

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