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Time course of the haemodynamic response to visual stimulation in migraine, measured using near-infrared spectroscopy

Coutts, Louise V and Cooper, Chris E and Elwell, Clare E and Wilkins, Arnold J (2012) 'Time course of the haemodynamic response to visual stimulation in migraine, measured using near-infrared spectroscopy.' Cephalalgia, 32 (8). pp. 621-629. ISSN 0333-1024

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Abstract

<jats:p> Background: In patients with migraine, an abnormally large haemodynamic response to epileptogenic visual stimulation has previously been observed, consistent with the hypothesis of a cortical hyperexcitability. Ophthalmic filters have been used in the treatment of migraine, and they reduce the haemodynamic response. </jats:p><jats:p> Methods: The present study used near-infrared spectroscopy (NIRS) to characterise the haemodynamic response to a range of visual stimuli in 20 patients with migraine (15 with aura and 5 without) and paired controls in order to assess the effect of ophthalmic treatment. In an initial study, the response to three stimuli (chequerboard, and two gratings of different spatial frequency) was measured. In a second study, using the mid-spatial frequency grating as stimulus, the response was compared when precision spectral filters (PSF), grey filters or filters of control colour were worn as ophthalmic lenses. </jats:p><jats:p> Results: In the first study the time course of the response differed between the groups. The difference was most distinct for the grating with mid-spatial frequency. In the second study the PSF broadened (normalised) the haemodynamic response in migraineurs relative to controls, consistent with fMRI BOLD findings and suggesting a physiological mechanism for their reported efficacy. In neither study were there differences in the amplitude of the response between migraine and control groups or indeed between filters. </jats:p><jats:p> Conclusion: The time course of the functional response as measured by NIRS may be an effective tool to track therapy with PSF and explore the mechanisms of visual stress in migraine. </jats:p>

Item Type: Article
Uncontrolled Keywords: Near-infrared spectroscopy; migraine; hyperexcitability; visual cortex; haemodynamic response latency; precision spectral filters
Subjects: R Medicine > RE Ophthalmology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Psychology, Department of
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 20 Sep 2012 09:15
Last Modified: 15 Jan 2022 00:21
URI: http://repository.essex.ac.uk/id/eprint/3836

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