Research Repository

Stem Cells in the Reproductive System

Kyurkchiev, Stanimir and Gandolfi, Fulvio and Hayrabedyan, Soren and Brevini, Tiziana AL and Dimitrov, Roumen and Fitzgerald, Justine S and Jabeen, Asma and Mourdjeva, Milena and Photini, Stella M and Spencer, Patrick and Fernández, Nelson and Markert, Udo R (2012) 'Stem Cells in the Reproductive System.' American Journal of Reproductive Immunology, 67 (6). pp. 445-462. ISSN 1046-7408

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This review article summarizes current knowledge on regulation, functions, and capacities of stem cells in the female and male reproductive tract. Major locations in which pluripotent cells reside and from where they can be isolated are the ovaries, the endometrium, the decidua, and the testis. They include oocytes, embryonic stem cells, trophoblast stem cells, and spermatogonial stem cells, but also several side populations, which can be obtained after certain isolation and culture procedures. The potential of pluripotent cells in the reproductive tract to differentiate is manifold, but heterogenous, depending upon their respective origin. As stem cells have a potential for future application in transplantation and regenerative medicine, this article also reviews the literature on major histocompatibility complex expression on stem cells of the reproductive tract, because of its immunogenic effects, but also because of its potential expression of HLA-G, a potent immunomodulator mainly associated with trophoblast cells. © 2012 John Wiley & Sons A/S.

Item Type: Article
Uncontrolled Keywords: Decidua; endometrium; major histocompatibility complex; oocytes; testis; trophoblast
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 22 Jan 2013 11:53
Last Modified: 18 Aug 2022 11:02

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