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The activation of the CGRP receptor

Barwell, J and Wheatley, M and Conner, AC and Taddese, B and Vohra, S and Reynolds, CA and Poyner, DR (2013) 'The activation of the CGRP receptor.' Biochemical Society Transactions, 41 (1). 180 - 184. ISSN 0300-5127

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Abstract

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs. © 2013 Biochemical Society.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Christopher Reynolds
Date Deposited: 02 Feb 2013 16:39
Last Modified: 30 Jan 2019 16:17
URI: http://repository.essex.ac.uk/id/eprint/5413

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