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Double nerve intraneural interface implant on a human amputee for robotic hand control

Rossini, Paolo M and Micera, Silvestro and Benvenuto, Antonella and Carpaneto, Jacopo and Cavallo, Giuseppe and Citi, Luca and Cipriani, Christian and Denaro, Luca and Denaro, Vincenzo and Di Pino, Giovanni and Ferreri, Florinda and Guglielmelli, Eugenio and Hoffmann, Klaus-Peter and Raspopovic, Stanisa and Rigosa, Jacopo and Rossini, Luca and Tombini, Mario and Dario, Paolo (2010) 'Double nerve intraneural interface implant on a human amputee for robotic hand control.' Clinical Neurophysiology, 121 (5). pp. 777-783. ISSN 1388-2457

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Abstract

Objectives: The principle underlying this project is that, despite nervous reorganization following upper limb amputation, original pathways and CNS relays partially maintain their function and can be exploited for interfacing prostheses. Aim of this study is to evaluate a novel peripheral intraneural multielectrode for multi-movement prosthesis control and for sensory feed-back, while assessing cortical reorganization following the re-acquired stream of data. Methods: Four intrafascicular longitudinal flexible multielectrodes (tf-LIFE4) were implanted in the median and ulnar nerves of an amputee; they reliably recorded output signals for 4 weeks. Artificial intelligence classifiers were used off-line to analyse LIFE signals recorded during three distinct hand movements under voluntary order. Results: Real-time control of motor output was achieved for the three actions. When applied off-line artificial intelligence reached >85% real-time correct classification of trials. Moreover, different types of current stimulation were determined to allow reproducible and localized hand/fingers sensations. Cortical organization was observed via TMS in parallel with partial resolution of symptoms due to the phantom-limb syndrome (PLS). Conclusions: tf-LIFE4s recorded output signals in human nerves for 4 weeks, though the efficacy of sensory stimulation decayed after 10 days. Recording from a number of fibres permitted a high percentage of distinct actions to be classified correctly. Reversal of plastic changes and alleviation of PLS represent corollary findings of potential therapeutic benefit. Significance: This study represents a breakthrough in robotic hand use in amputees. © 2010 International Federation of Clinical Neurophysiology.

Item Type: Article
Uncontrolled Keywords: Intraneural interface; Limb amputation; Phantom-limb syndrome; Neural plasticity; Transcranial magnetic stimulation; Hand prosthesis
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > R Medicine (General)
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Science and Health
Faculty of Science and Health > Computer Science and Electronic Engineering, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 11 Feb 2013 15:05
Last Modified: 15 Jan 2022 00:21
URI: http://repository.essex.ac.uk/id/eprint/5488

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