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Double nerve intraneural interface implant on a human amputee for robotic hand control

Rossini, PM and Micera, S and Benvenuto, A and Carpaneto, J and Cavallo, G and Citi, L and Cipriani, C and Denaro, L and Denaro, V and Di Pino, G and Ferreri, F and Guglielmelli, E and Hoffmann, KP and Raspopovic, S and Rigosa, J and Rossini, L and Tombini, M and Dario, P (2010) 'Double nerve intraneural interface implant on a human amputee for robotic hand control.' Clinical Neurophysiology, 121 (5). 777 - 783. ISSN 1388-2457

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Abstract

Objectives: The principle underlying this project is that, despite nervous reorganization following upper lim b amputation, original pathways and CNS relays partially maintain their function and can be exploited for interfacing prostheses. Aim of this study is to evaluate a novel peripheral intraneural multielectrode for multi-movement prosthesis control and for sensory feed-back, while assessing cortical reorganization following the re-acquired stream of data. Methods: Four intrafascicular longitudinal flexible multielectrodes (tf-LIFE4) were implanted in the median and ulnar nerves of an amputee; they reliably recorded output signals for 4 weeks. Artificial intelligence classifiers were used off-line to analyse LIFE signals recorded during three distinct hand movements under voluntary order. Results: Real-time control of motor output was achieved for the three actions. When applied off-line artificial intelligence reached > 85% real-time correct classification of trials. Moreover, different types of current stimulation were determined to allow reproducible and localized hand/fingers sensations. Cortical organization was observed via TMS in parallel with partial resolution of symptoms due to the phantom-limb syndrome (PLS). Conclusions: tf-LIFE4s recorded output signals in human nerves for 4 weeks, though the efficacy of sensory stimulation decayed after 10 days. Recording from a number of fibres permitted a high percentage of distinct actions to be classified correctly. Reversal of plastic changes and alleviation of PLS represent corollary findings of potential therapeutic benefit. Significance: This study represents a breakthrough in robotic hand use in amputees. © 2010 International Federation of Clinical Neurophysiology.

Item Type: Article
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > R Medicine (General)
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Jim Jamieson
Date Deposited: 11 Feb 2013 15:05
Last Modified: 14 Nov 2017 19:15
URI: http://repository.essex.ac.uk/id/eprint/5488

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