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Structural and regulatory genes required to make the gas dimethyl sulfide in bacteria

Todd, JD and Rogers, R and You, GL and Wexler, M and Bond, PL and Sun, L and Curson, ARJ and Malin, G and Steinke, M and Johnston, AWB (2007) 'Structural and regulatory genes required to make the gas dimethyl sulfide in bacteria.' Science, 315 (5812). 666 - 669. ISSN 0036-8075

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Dimethyl sulfide (DMS) is a key compound in global sulfur and carbon cycles. DMS oxidation products cause cloud nucleation and may affect weather and climate. DMS is generated largely by bacterial catabolism of dimethylsulfoniopropionate (DMSP), a secondary metabolite made by marine algae. We demonstrate that the bacterial gene dddD is required for this process and that its transcription is induced by the DMSP substrate. Cloned dddD from the marine bacterium Marinomonas and from two bacterial strains that associate with higher plants, the N2-fixing symbiont Rhizobium NGR234 and the root-colonizing Burkholderia cepacia AMMD, conferred to Escherichia coli the ability to make DMS from DMSP. The inferred enzymatic mechanism for DMS liberation involves an initial step in which DMSP is modified by addition of acyl coenzyme A, rather than the immediate release of DMS by a DMSP lyase, the previously suggested mechanism.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Michael Steinke
Date Deposited: 07 Mar 2013 14:54
Last Modified: 30 Jun 2021 10:15

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