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Handedness is mainly associated with an asymmetry of corticospinal excitability and not of transcallosal inhibition

De Gennaro, Luigi and Cristiani, Riccardo and Bertini, Mario and Curcio, Giuseppe and Ferrara, Michele and Fratello, Fabiana and Romei, Vincenzo and Rossini, Paolo M (2004) 'Handedness is mainly associated with an asymmetry of corticospinal excitability and not of transcallosal inhibition.' Clinical Neurophysiology, 115 (6). pp. 1305-1312. ISSN 1388-2457

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Objective The study aims to compare transcallosal inhibition (TI), as assessed by the paired-pulse transcranial magnetic stimulation (TMS) technique, in a sample of right-handed subjects (RH) and left-handed subjects (LH). Motor thresholds (MTs) and motor evoked potential (MEP) amplitudes were also measured in the two groups, as an index of corticospinal activity. Methods Thirty-two normal subjects (16 RH and 16 LH) were recorded with a paired-pulse TMS paradigm (intensity of both pulses=120% of MT). The inter-stimulus intervals (ISIs) were 2, 4, 6, 8, 10, 12, 14, 16, 18, and 20 ms for both motor cortices, and MEP responses were recorded from the abductor digiti minimi muscles. Results Both groups showed a clear TI centred around the 12 ms ISI, but no difference was found as a function of handedness or of hemisphere. On the other hand, the two groups differed in terms of corticospinal activity, since the hand motor dominant hemisphere had lower MTs than the non-dominant one in LH, and larger MEP amplitudes for the right hand were found in RH. Conclusions Results point to a functional asymmetry of the motor cortex on the hand-dominant versus the non-dominant hemisphere, while handedness does not seem associated with functional differences in callosal inhibition, as measured by the inter-hemispheric paired-pulse TMS technique. © 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: transcranial magnetic stimulation; handedness; paired-pulse technique; transcallosal inhibition; corpus callosum; corticospinal system; gender
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science and Health
Faculty of Science and Health > Psychology, Department of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 12 May 2013 17:43
Last Modified: 15 Jan 2022 00:31

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