Dudley, R and Alsam, S and Khan, NA (2008) 'The role of proteases in the differentiation of Acanthamoeba castellanii.' FEMS microbiology letters, 286 (1). pp. 9-15. ISSN 0378-1097
Full text not available from this repository.Abstract
Proteases are significant determinants of protozoan pathogenicity and cytolysis of host cells. However, there is now growing evidence of their involvement in cellular differentiation. Acanthamoeba castellanii of the T4 genotype elaborates a number of proteases, which are inhibited by the serine protease inhibitor phenylmethylsulphonyl fluoride. Using this and other selective protease inhibitors, in tandem with siRNA primers, specific to the catalytic site of Acanthamoeba serine proteases, we demonstrate that serine protease activity is crucial for the differentiation of A. castellanii. Furthermore, both encystment and excystment of A. castellanii was found to be dependent on serine protease function.
Item Type: | Article |
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Uncontrolled Keywords: | Acanthamoeba; differentiation; serine proteases |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Elements |
Depositing User: | Elements |
Date Deposited: | 16 Sep 2011 09:02 |
Last Modified: | 06 Jan 2022 13:17 |
URI: | http://repository.essex.ac.uk/id/eprint/675 |
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