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Modelling of mitochondrial oxygen consumption and NIRS detection of cytochrome oxidase redox state

Banaji, M and Mallet, A and Elwell, CE and Nicholls, P and Tachtsidis, I and Smith, M and Cooper, CE (2010) 'Modelling of mitochondrial oxygen consumption and NIRS detection of cytochrome oxidase redox state.' Advances in Experimental Medicine and Biology, 662. 285 - 291. ISSN 0065-2598

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Abstract

In recent years there has been widespread use of near infrared spectroscopy (NIRS) to monitor the brain. The signals of interest include changes in the levels of oxygenated and deoxygenated haemoglobin and tissue oxygen saturation. In addition to oxy- and deoxy-haemoglobin, the CuA centre in cytochromec- oxidase (CCO) is a significant NIR absorber, giving rise to another signal termed the DoxCCO signal. This signal has great potential as a marker of cellular oxygen metabolism, but is also the hardest to interpret. Here we use a recently constructed model to predict NIRS signal changes, and compare the model output to data from an in vivo hypoxia study in healthy adults. Our findings indicate strongly that the DoxCCO signal contains useful information despite the noise, and has responses consistent with the known physiology. © Springer Science+Business Media, LLC 2010.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Sport, Rehabilitation and Exercise Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 15 Sep 2011 12:33
Last Modified: 04 Sep 2017 16:15
URI: http://repository.essex.ac.uk/id/eprint/696

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