Research Repository

Modelling of Mitochondrial Oxygen Consumption and NIRS Detection of Cytochrome Oxidase Redox State

Banaji, Murad and Mallet, Alfred and Elwell, Clare E and Nicholls, Peter and Tachtsidis, Ilias and Smith, Martin and Cooper, Chris E (2010) 'Modelling of Mitochondrial Oxygen Consumption and NIRS Detection of Cytochrome Oxidase Redox State.' Advances in Experimental Medicine and Biology, 662. pp. 285-291. ISSN 0065-2598

Full text not available from this repository.


In recent years there has been widespread use of near infrared spectroscopy (NIRS) to monitor the brain. The signals of interest include changes in the levels of oxygenated and deoxygenated haemoglobin and tissue oxygen saturation. In addition to oxy- and deoxy-haemoglobin, the CuA centre in cytochromec- oxidase (CCO) is a significant NIR absorber, giving rise to another signal termed the DoxCCO signal. This signal has great potential as a marker of cellular oxygen metabolism, but is also the hardest to interpret. Here we use a recently constructed model to predict NIRS signal changes, and compare the model output to data from an in vivo hypoxia study in healthy adults. Our findings indicate strongly that the DoxCCO signal contains useful information despite the noise, and has responses consistent with the known physiology. © Springer Science+Business Media, LLC 2010.

Item Type: Article
Uncontrolled Keywords: Mitochondria; Humans; Electron Transport Complex IV; Spectroscopy, Near-Infrared; Cell Hypoxia; Oxidation-Reduction; Oxygen Consumption; Models, Biological
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 15 Sep 2011 12:33
Last Modified: 15 Jan 2022 00:21

Actions (login required)

View Item View Item