Research Repository

A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges

Banaji, Murad and Mallet, Alfred and Elwell, Clare E and Nicholls, Peter and Cooper, Chris E (2008) 'A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges.' PLoS Computational Biology, 4 (11). e1000212-e1000212. ISSN 1553-734X

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We construct a model of brain circulation and energy metabolism. The model is designed to explain experimental data and predict the response of the circulation and metabolism to a variety of stimuli, in particular, changes in arterial blood pressure, CO2 levels, O2 levels, and functional activation. Significant model outputs are predictions about blood flow, metabolic rate, and quantities measurable noninvasively using near-infrared spectroscopy (NIRS), including cerebral blood volume and oxygenation and the redox state of the CuA centre in cytochrome c oxidase. These quantities are now frequently measured in clinical settings; however the relationship between the measurements and the underlying physiological events is in general complex. We anticipate that the model will play an important role in helping to understand the NIRS signals, in particular, the cytochrome signal, which has been hard to interpret. A range of model simulations are presented, and model outputs are compared to published data obtained from both in vivo and in vitro settings. The comparisons are encouraging, showing that the model is able to reproduce observed behaviour in response to various stimuli. © 2008 Banaji et al.

Item Type: Article
Uncontrolled Keywords: Brain; Animals; Humans; Oxygen; Electron Transport Complex IV; Spectroscopy, Near-Infrared; Systems Biology; Energy Metabolism; Oxidation-Reduction; Oxygen Consumption; Cerebrovascular Circulation; Thermodynamics; Models, Biological; Hemodynamics
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 16 Sep 2011 09:01
Last Modified: 15 Jan 2022 00:21

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