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Glycodelin-A as a paracrine regulator in early pregnancy

Lee, CL and Lam, KKW and Koistinen, H and Seppala, M and Kurpisz, M and Fernandez, N and Pang, RTK and Yeung, WSB and Chiu, PCN (2011) Glycodelin-A as a paracrine regulator in early pregnancy. In: UNSPECIFIED, ? - ?.

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Abstract

Glycodelin-A (GdA) is a glycoprotein secreted from the endometrial glands and decidual glandular epithelium. Given its abundance and ubiquitous distribution in the first trimester uterus, GdA may be involved in early placental development via its modulatory effect on immune and trophoblast cells. GdA inhibits activation and proliferation, and induces apoptosis of T cells. By selectively inducing Th1 cell death, GdA may shift the Th1/Th2 ratio at the feto-maternal interface. This is also achieved indirectly through enhanced expression of Fas in the Th1 cells, thus making them vulnerable to cell death through Fas ligand expressed on trophoblast, endometrial, and activated T helper cells. GdA also promotes secretion of the Th2 cytokines IL-6 and IL-13 from NK cells, and induces immunological tolerance of dendritic cells and apoptosis of monocytes. Specific glycosylation is a prerequisite for the biological activities of GdA. Reduction in α2-6 sialylation of GdA, as in gestational diabetes, is associated with impairment of its T cell apoptosis-inducing activities. This review integrates recent studies on GdA and its role as a paracrine regulator in early pregnancy. © 2011 Elsevier Ireland Ltd.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Additional Information: Published proceedings: Journal of Reproductive Immunology
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 06 Oct 2011 14:53
Last Modified: 20 Aug 2019 17:15
URI: http://repository.essex.ac.uk/id/eprint/816

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