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The Yeast<i>TEL1</i>Gene Partially Substitutes for Human<i>ATM</i>in Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells

Fritz, Eberhard and Friedl, Anna A and Zwacka, Ralf M and Eckardt-Schupp, Friederike and Meyn, M Stephen (2000) 'The Yeast<i>TEL1</i>Gene Partially Substitutes for Human<i>ATM</i>in Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells.' Molecular Biology of the Cell, 11 (8). pp. 2605-2616. ISSN 1059-1524

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Abstract

<jats:p>Homozygous mutations in the human ATM gene lead to a pleiotropic clinical phenotype of ataxia-telangiectasia (A-T) patients and correlating cellular deficiencies in cells derived from A-T donors. Saccharomyces cerevisiae tel1 mutants lacking Tel1p, which is the closest sequence homologue to the ATM protein, share some of the cellular defects with A-T. Through genetic complementation of A-T cells with the yeast TEL1 gene, we provide evidence that Tel1p can partially compensate for ATM in suppressing hyperrecombination, radiation-induced apoptosis, and telomere shortening. Complementation appears to be independent of p53 activation. The data provided suggest that TEL1 is a functional homologue of human ATM in yeast, and they help to elucidate different cellular and biochemical pathways in human cells regulated by the ATM protein.</jats:p>

Item Type: Article
Uncontrolled Keywords: Cell Line, Transformed; Telomere; Fibroblasts; Humans; Saccharomyces cerevisiae; Intracellular Signaling Peptides and Proteins; Cell Cycle Proteins; DNA-Binding Proteins; Fungal Proteins; Saccharomyces cerevisiae Proteins; Tumor Suppressor Proteins; Genetic Complementation Test; Transfection; Apoptosis; Recombination, Genetic; Mutation; Gamma Rays; Tumor Suppressor Protein p53; Ataxia Telangiectasia Mutated Proteins; Protein Serine-Threonine Kinases
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 03 Jul 2017 09:08
Last Modified: 18 Aug 2022 11:33
URI: http://repository.essex.ac.uk/id/eprint/8340

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