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Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation

Zwacka, Ralf M and Zhou, Weihong and Zhang, Yulong and Darby, Christine J and Dudus, Lorita and Halldorson, Jeff and Oberley, Larry and Engelhardt, John F (1998) 'Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation.' Nature Medicine, 4 (6). pp. 698-704. ISSN 1078-8956

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Abstract

Liver transplantation is the only therapeutic strategy for many inherited and acquired diseases. The formation of reactive oxygen species following ischemia/reperfusion is a cause of hepatocellular injury during transplantation. This report describes the therapeutic application of mitochondrial superoxide dismutase gene transfer to the liver for acute ischemia/reperfusion injury. Recombinant adenoviral expression of mitochondrial superoxide dismutase in mouse liver prior to lobar ischemia/reperfusion significantly reduced acute liver damage and associated redox activation of both NF-κB and AP1. These immediate early transcription factors represent common pathways by which cells respond to environmental stress. This work provides the foundation for redox-mediated gene therapies directed at ameliorating ischemia/reperfusion injury and associated acute rejection in orthotopic liver transplantation.

Item Type: Article
Uncontrolled Keywords: Liver; Mitochondria, Liver; Animals; Mice; Mice, Nude; Reperfusion Injury; Superoxide Dismutase; NF-kappa B; Proto-Oncogene Proteins; Recombinant Proteins; Transcription Factors; Transcription Factor AP-1; Gene Expression; Oxidation-Reduction; Transgenes; Male; Transcription Factor RelB; Transcriptional Activation; Genetic Therapy
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 12 Jul 2017 16:14
Last Modified: 15 Jan 2022 00:34
URI: http://repository.essex.ac.uk/id/eprint/8353

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