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The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species

Zwacka, RM and Reuter, A and Pfaff, E and Moll, J and Gorgas, K and Karasawa, M and Weiher, H (1994) 'The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species.' EMBO Journal, 13 (21). 5129 - 5134. ISSN 0261-4189

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Abstract

The mutant mouse strain Mpv17 carries a retroviral insert in its genome which inactivates the Mpv17 gene. At a young age these mice develop glomerulosclerosis and nephrotic syndrome which resembles human disease. We show here that the Mpv17 gene product is highly conserved and encodes a peroxisomal protein. Loss of the Mpv17 protein does not impair peroxisome biogenesis but instead leads to a reduced ability to produce reactive oxygen species (ROS). In turn, overproduction of the Mpv17 gene in transfected cells results in dramatically enhanced levels of intracellular ROS indicating a direct involvement of Mpv17 in ROS production. These data reveal a role for the Mpv17 protein in peroxisomal reactive oxygen metabolism and establish a novel link between peroxisomal ROS production and glomerulosclerosis.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 04 Jul 2017 11:26
Last Modified: 17 Aug 2017 17:55
URI: http://repository.essex.ac.uk/id/eprint/8360

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