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BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours

D'Arcy, V and Pore, N and Docquier, F and Abdullaev, ZK and Chernukhin, I and Kita, GX and Rai, S and Smart, M and Farrar, D and Pack, S and Lobanenkov, V and Klenova, E (2008) 'BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours.' British Journal of Cancer, 98 (3). 571 - 579. ISSN 0007-0920

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Abstract

BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as follows: (1) to investigate BORIS expression in breast cells and tumours using immunohistochemical staining, western and real-time RT-PCR analyses and (2) assess potential correlation between BORIS levels in tumours with clinical/pathological parameters. BORIS was detected in all 18 inspected breast cell lines, but not in a primary normal breast cell culture. In 70.7% (41 of 58 cases) BORIS was observed in breast tumours. High levels of BORIS correlated with high levels of progesterone receptor (PR) and oestrogen receptor (ER). The link between BORIS and PR/ER was further confirmed by the ability of BORIS to activate the promoters of the PR and ER genes in the reporter assays. Detection of BORIS in a high proportion of breast cancer patients implies potential practical applications of BORIS as a molecular biomarker of breast cancer. This may be important for diagnosis of the condition and for the therapeutic use of BORIS. The ability of BORIS to activate promoters of the RP and ER genes points towards possible involvement of BORIS in the establishment, progression and maintenance of breast tumours. © 2008 Cancer Research UK.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Biological Sciences, School of
Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 23 Sep 2011 09:01
Last Modified: 23 Jan 2019 01:15
URI: http://repository.essex.ac.uk/id/eprint/844

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