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Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell.

Marco, Antonio and Marín, Ignacio (2009) 'Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell.' BMC Syst Biol, 3. 69 - ?. ISSN 1752-0509

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Abstract

BACKGROUND: The characterization of the global functional structure of a cell is a major goal in bioinformatics and systems biology. Gene Ontology (GO) and the protein-protein interaction network offer alternative views of that structure. RESULTS: This study presents a comparison of the global structures of the Gene Ontology and the interactome of Saccharomyces cerevisiae. Sensitive, unsupervised methods of clustering applied to a large fraction of the proteome led to establish a GO-interactome correlation value of +0.47 for a general dataset that contains both high and low-confidence interactions and +0.58 for a smaller, high-confidence dataset. CONCLUSION: The structures of the yeast cell deduced from GO and interactome are substantially congruent. However, some significant differences were also detected, which may contribute to a better understanding of cell function and also to a refinement of the current ontologies.

Item Type: Article
Uncontrolled Keywords: Databases, Protein, Protein Interaction Mapping, Proteome, Ribonucleoproteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Systems Biology
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Antonio Marco
Date Deposited: 23 Mar 2015 19:28
Last Modified: 14 Oct 2019 23:16
URI: http://repository.essex.ac.uk/id/eprint/8498

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