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Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell

Marco, Antonio and Marín, Ignacio (2009) 'Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell.' BMC Systems Biology, 3 (1). 69-. ISSN 1752-0509

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<h4>Background</h4>The characterization of the global functional structure of a cell is a major goal in bioinformatics and systems biology. Gene Ontology (GO) and the protein-protein interaction network offer alternative views of that structure.<h4>Results</h4>This study presents a comparison of the global structures of the Gene Ontology and the interactome of Saccharomyces cerevisiae. Sensitive, unsupervised methods of clustering applied to a large fraction of the proteome led to establish a GO-interactome correlation value of +0.47 for a general dataset that contains both high and low-confidence interactions and +0.58 for a smaller, high-confidence dataset.<h4>Conclusion</h4>The structures of the yeast cell deduced from GO and interactome are substantially congruent. However, some significant differences were also detected, which may contribute to a better understanding of cell function and also to a refinement of the current ontologies.

Item Type: Article
Uncontrolled Keywords: Saccharomyces cerevisiae; Ribonucleoproteins; Saccharomyces cerevisiae Proteins; Proteome; Protein Interaction Mapping; Systems Biology; Databases, Protein
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 23 Mar 2015 19:28
Last Modified: 18 Aug 2022 11:29

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