Marco, Antonio and Marín, Ignacio (2009) 'Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell.' BMC Syst Biol, 3. 69 - ?. ISSN 1752-0509

Preview

Text 2009_BMCSystBiol_GO.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview

Abstract

BACKGROUND: The characterization of the global functional structure of a cell is a major goal in bioinformatics and systems biology. Gene Ontology (GO) and the protein-protein interaction network offer alternative views of that structure. RESULTS: This study presents a comparison of the global structures of the Gene Ontology and the interactome of Saccharomyces cerevisiae. Sensitive, unsupervised methods of clustering applied to a large fraction of the proteome led to establish a GO-interactome correlation value of +0.47 for a general dataset that contains both high and low-confidence interactions and +0.58 for a smaller, high-confidence dataset. CONCLUSION: The structures of the yeast cell deduced from GO and interactome are substantially congruent. However, some significant differences were also detected, which may contribute to a better understanding of cell function and also to a refinement of the current ontologies.

Item Type:	Article
Uncontrolled Keywords:	Databases, Protein, Protein Interaction Mapping, Proteome, Ribonucleoproteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Systems Biology
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Science and Health > Biological Sciences, School of
Depositing User:	Antonio Marco
Date Deposited:	23 Mar 2015 19:28
Last Modified:	17 Aug 2017 17:54
URI:	http://repository.essex.ac.uk/id/eprint/8498

Actions (login required)

View Item