Marco, Antonio and Marín, Ignacio (2009) 'Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell.' BMC Systems Biology, 3 (1). 69-. ISSN 1752-0509
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Abstract
<h4>Background</h4>The characterization of the global functional structure of a cell is a major goal in bioinformatics and systems biology. Gene Ontology (GO) and the protein-protein interaction network offer alternative views of that structure.<h4>Results</h4>This study presents a comparison of the global structures of the Gene Ontology and the interactome of Saccharomyces cerevisiae. Sensitive, unsupervised methods of clustering applied to a large fraction of the proteome led to establish a GO-interactome correlation value of +0.47 for a general dataset that contains both high and low-confidence interactions and +0.58 for a smaller, high-confidence dataset.<h4>Conclusion</h4>The structures of the yeast cell deduced from GO and interactome are substantially congruent. However, some significant differences were also detected, which may contribute to a better understanding of cell function and also to a refinement of the current ontologies.
Item Type: | Article |
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Uncontrolled Keywords: | Saccharomyces cerevisiae; Ribonucleoproteins; Saccharomyces cerevisiae Proteins; Proteome; Protein Interaction Mapping; Systems Biology; Databases, Protein |
Subjects: | Q Science > Q Science (General) |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Elements |
Depositing User: | Elements |
Date Deposited: | 23 Mar 2015 19:28 |
Last Modified: | 15 Jan 2022 00:54 |
URI: | http://repository.essex.ac.uk/id/eprint/8498 |
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