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Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention

Mason, Jody M (2010) 'Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention.' Future Medicinal Chemistry, 2 (12, SI). pp. 1813-1822. ISSN 1756-8919

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Abstract

The concept of peptides as therapeutic agents has been historically disregarded by the pharmaceutical industry on account of their susceptibility to degradation, their size and consequent limitations in methods of delivery. Recently, however, there has been a surge of interest in peptides and their mimetics as potential antagonists for therapeutic intervention. This is in part due to the increased half-life and oral availability that has been achieved for a number of peptide-based systems, the introduction and acceptance of alternative delivery methods, and the prevalence of proteomics to identify countless protein-protein interaction targets. The use of peptides and molecules that mimic their function therefore has great potential to effectively target a range of proteins that are pathogenically implicated in numerous diseases.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 09 Oct 2011 07:36
Last Modified: 16 Dec 2014 11:19
URI: http://repository.essex.ac.uk/id/eprint/851

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