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Circulating nucleic acids as biomarkers of prostate cancer

Sita-Lumsden, Ailsa and Fletcher, Claire E and Dart, D Alwyn and Brooke, Greg N and Waxman, Jonathan and Bevan, Charlotte L (2013) 'Circulating nucleic acids as biomarkers of prostate cancer.' Biomarkers in Medicine, 7 (6). pp. 867-877. ISSN 1752-0363

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Abstract

<jats:p> Prostate cancer, the most common cancer of western men, requires new biomarkers, especially given that the benefits of PSA testing remain uncertain. Nucleic acids can now be accurately and sensitively detected in human blood. Over the last decade, investigations into utility of circulating cell-free miRNA, DNA and mRNA as novel biomarkers have expanded exponentially. In the near future, they may be routinely used to accurately diagnose cancers, stratify indolent from aggressive disease and inform treatment decisions. However, advancement of such tests into clinical settings is hampered by technical problems with assay specificity and sensitivity, and small study sizes. This review highlights the different forms of circulating nucleic acids and those that show the most potential as viable biomarkers for prostate cancer. </jats:p>

Item Type: Article
Uncontrolled Keywords: biomarkers; cell-free DNA; circulating nucleic acids; microRNA; miRNA; mRNA; prostate cancer
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 27 Jan 2014 13:39
Last Modified: 15 Jan 2022 00:21
URI: http://repository.essex.ac.uk/id/eprint/8650

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