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A peptide-centric approach to breast cancer biomarker discovery utilizing label-free multiple reaction monitoring mass spectrometry

Metodieva, G and Greenwood, C and Alldridge, L and Sauven, P and Metodiev, M (2009) 'A peptide-centric approach to breast cancer biomarker discovery utilizing label-free multiple reaction monitoring mass spectrometry.' Proteomics - Clinical Applications, 3 (1). 78 - 82. ISSN 1862-8346

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Abstract

We report an approach for multiplex analysis of cancer biomarkers based on the measurement of diagnostic peptides in whole tissue protein digests. Label-free quantitation with MS3 multiple reaction monitoring (MRM) was developed to afford accurate analysis of prospective marker peptides in a panel of breast tumors. This approach provides an economical and robust alternative to stable isotope-based methods. It is equally applicable to the analysis of samples derived from tissue biopsy, aspirate, or plasma and can be easily translated to clinic. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 06 Oct 2011 13:21
Last Modified: 10 Oct 2019 21:15
URI: http://repository.essex.ac.uk/id/eprint/869

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