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Evolution and conservation in human parechovirus genomes

Williams, Çiğdem H and Panayiotou, Maria and Girling, Gareth D and Peard, Curtis I and Oikarinen, Sami and Hyöty, Heikki and Stanway, Glyn (2009) 'Evolution and conservation in human parechovirus genomes.' Journal of General Virology, 90 (7). 1702 - 1712. ISSN 0022-1317

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<jats:p>Human parechoviruses (HPeVs) are frequent pathogens with a seroprevalance of over 90 % in adults. Recent studies on these viruses have increased the number of HPeV types to eight. Here we analyse the complete genome of one clinical isolate, PicoBank/HPeV1/a, and VP1 and 3D protein sequences of PicoBank/HPeV6/a, isolated from the same individual 13 months later. PicoBank/HPeV1/a is closely related to other recent HPeV1 isolates but is distinct from the HPeV1 Harris prototype isolated 50 years ago. The availability of an increasing number of HPeV sequences has allowed a detailed analysis of these viruses. The results add weight to the observations that recombination plays a role in the generation of HPeV diversity. An important finding is the presence of unexpected conservation of codons utilized in part of the 3D-encoding region, some of which can be explained by the presence of a phylogenetically conserved predicted secondary structure domain. This suggests that in addition to the <jats:italic>cis</jats:italic>-acting replication element, RNA secondary structure domains in coding regions play a key role in picornavirus replication.</jats:p>

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 09 Oct 2011 07:04
Last Modified: 02 Nov 2020 11:15

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