Research Repository

Evolution and conservation in human parechovirus genomes

Williams, CH and Panayiotou, M and Girling, GD and Peard, CI and Oikarinen, S and Hyoty, H and Stanway, G (2009) 'Evolution and conservation in human parechovirus genomes.' Journal of General Virology, 90 (7). pp. 1702-1712. ISSN 0022-1317

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Human parechoviruses (HPeVs) are frequent pathogens with a seroprevalance of over 90% in adults. Recent studies on these viruses have increased the number of HPeV types to eight. Here we analyse the complete genome of one clinical isolate, PicoBank/HPeV1/a, and VP1 and 3D protein sequences of PicoBank/HPeV6/a, isolated from the same individual 13 months later. PicoBank/HPeV1/a is closely related to other recent HPeV1 isolates but is distinct from the HPeV1 Harris prototype isolated 50 years ago. The availability of an increasing number of HPeV sequences has allowed a detailed analysis of these viruses. The results add weight to the observations that recombination plays a role in the generation of HPeV diversity. An important finding is the presence of unexpected conservation of codons utilized in part of the 3D-encoding region, some of which can be explained by the presence of a phylogenetically conserved predicted secondary structure domain. This suggests that in addition to the cis-acting replication element, RNA secondary structure domains in coding regions play a key role in picornavirus replication.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 09 Oct 2011 07:04
Last Modified: 06 Jan 2022 13:34

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