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Widespread recombination within human parechoviruses: analysis of temporal dynamics and constraints

Benschop, KSM and Williams, ÇH and Wolthers, KC and Stanway, G and Simmonds, P (2008) 'Widespread recombination within human parechoviruses: analysis of temporal dynamics and constraints.' Journal of General Virology, 89 (4). 1030 - 1035. ISSN 0022-1317

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Abstract

<jats:p>Human parechoviruses (HPeVs), members of the family <jats:italic>Picornaviridae</jats:italic>, are classified into six types. To investigate the dynamics and likelihood of recombination among HPeVs, we compared phylogenies of two distant regions (VP1 and 3Dpol) of 37 HPeV isolates (types 1 and 3–5) and prototype sequences (types 1–6). Evidence for frequent recombination between HPeV1, 4, 5 and 6 was found. The likelihood of recombination was correlated with the degree of VP1 divergence and differences in isolation dates, both indicative of evolutionary times of divergence. These temporal dynamics were found to be most similar to those of human enterovirus species B variants. In contrast, HPeV3 remained phylogenetically distinct from other types throughout the genome. As HPeV3 is equally divergent in nucleotide sequence from the other HPeV types, its genetic isolation may reflect different biology and changed cellular tropisms, arising from the deletion of the RGD motif, and likely use of a non-integrin receptor.</jats:p>

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 09 Oct 2011 07:09
Last Modified: 16 Nov 2020 11:15
URI: http://repository.essex.ac.uk/id/eprint/974

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