Moroz, Tracy and Hapuarachchi, Tharindi and Bainbridge, Alan and Price, David and Cady, Ernest and Baer, Ether and Broad, Kevin and Ezzati, Mojgan and Thomas, David and Golay, Xavier and Robertson, Nicola J and Cooper, Chris E and Tachtsidis, Ilias (2013) Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating Brain Energetics. In: UNSPECIFIED, ? - ?, United States.
Moroz, Tracy and Hapuarachchi, Tharindi and Bainbridge, Alan and Price, David and Cady, Ernest and Baer, Ether and Broad, Kevin and Ezzati, Mojgan and Thomas, David and Golay, Xavier and Robertson, Nicola J and Cooper, Chris E and Tachtsidis, Ilias (2013) Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating Brain Energetics. In: UNSPECIFIED, ? - ?, United States.
Moroz, Tracy and Hapuarachchi, Tharindi and Bainbridge, Alan and Price, David and Cady, Ernest and Baer, Ether and Broad, Kevin and Ezzati, Mojgan and Thomas, David and Golay, Xavier and Robertson, Nicola J and Cooper, Chris E and Tachtsidis, Ilias (2013) Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating Brain Energetics. In: UNSPECIFIED, ? - ?, United States.
Abstract
We have developed a computational model to simulate hypoxia-ischaemia (HI) in the neonatal piglet brain. It has been extended from a previous model by adding the simulation of carotid artery occlusion and including pH changes in the cytoplasm. Here, simulations from the model are compared with near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (MRS) measurements from two piglets during HI and short-term recovery. One of these piglets showed incomplete recovery after HI, and this is modelled by considering some of the cells to be dead. This is consistent with the results from MRS and the redox state of cytochrome-c-oxidase as measured by NIRS. However, the simulations do not match the NIRS haemoglobin measurements. The model therefore predicts that further physiological changes must also be taking place if the hypothesis of dead cells is correct. © 2013 Springer Science+Business Media New York.
| Item Type: | Conference or Workshop Item (UNSPECIFIED) |
|---|---|
| Additional Information: | Published proceedings: Advances in Experimental Medicine and Biology |
| Uncontrolled Keywords: | Carotid Arteries; Brain; Animals; Animals, Newborn; Swine; Hypoxia-Ischemia, Brain; Disease Models, Animal; Electron Transport Complex IV; Hemoglobins; Spectroscopy, Near-Infrared; Magnetic Resonance Spectroscopy; Energy Metabolism; Oxidation-Reduction; Oxygen Consumption; Cerebrovascular Circulation; Hydrogen-Ion Concentration |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 23 Dec 2014 11:26 |
| Last Modified: | 30 Oct 2024 19:54 |
| URI: | http://repository.essex.ac.uk/id/eprint/10210 |