Querol Cano, Laia and Lavery, Derek N and Sin, Soraya and Spanjaard, Emma and Brooke, Greg N and Tilman, Jessica D and Abroaf, Ahmed and Gaughan, Luke and Robson, Craig N and Heer, Rakesh and Mauri, Francesco and de Rooij, Johan and Driouch, Keltouma and Bevan, Charlotte L (2015) The co‐chaperone p23 promotes prostate cancer motility and metastasis. Molecular Oncology, 9 (1). pp. 295-308. DOI https://doi.org/10.1016/j.molonc.2014.08.014
Querol Cano, Laia and Lavery, Derek N and Sin, Soraya and Spanjaard, Emma and Brooke, Greg N and Tilman, Jessica D and Abroaf, Ahmed and Gaughan, Luke and Robson, Craig N and Heer, Rakesh and Mauri, Francesco and de Rooij, Johan and Driouch, Keltouma and Bevan, Charlotte L (2015) The co‐chaperone p23 promotes prostate cancer motility and metastasis. Molecular Oncology, 9 (1). pp. 295-308. DOI https://doi.org/10.1016/j.molonc.2014.08.014
Querol Cano, Laia and Lavery, Derek N and Sin, Soraya and Spanjaard, Emma and Brooke, Greg N and Tilman, Jessica D and Abroaf, Ahmed and Gaughan, Luke and Robson, Craig N and Heer, Rakesh and Mauri, Francesco and de Rooij, Johan and Driouch, Keltouma and Bevan, Charlotte L (2015) The co‐chaperone p23 promotes prostate cancer motility and metastasis. Molecular Oncology, 9 (1). pp. 295-308. DOI https://doi.org/10.1016/j.molonc.2014.08.014
Abstract
<jats:p>Prostate cancer is an androgen receptor (AR)‐dependent malignancy at initiation and progression, therefore hormone therapy is the primary line of systemic treatment. Despite initial disease regression, tumours inevitably recur and progress to an advanced castration‐resistant state a major feature of which is metastasis to the bone. Up‐regulation of AR cofactors and chaperones that overcome low hormone conditions to maintain basal AR activity has been postulated as a mechanism of therapy relapse.</jats:p><jats:p>p23, an essential component of the apo‐AR complex, acts also after ligand binding to increase AR transcriptional activity and target gene expression, partly by increasing chromatin‐loaded holo‐receptor‐complexes. Immunohistochemical studies have demonstrated increased p23 expression in advanced prostate cancer. Here, we further characterise p23 roles in AR signalling and show that it modulates cytosolic AR levels in the absence of hormone, confirming a chaperoning function in the aporeceptor complex and suggesting p23 upregulates AR signalling at multiple stages. Moreover, p23 protein levels significantly increased upon treatment with not only androgen but also clinically relevant anti‐androgens. This was in contrast to the HSP90 inhibitor 17‐AAG, which did not modulate expression of the cochaperone – important given the HSP90‐independent roles we and others have previously described for p23.</jats:p><jats:p>Further, we demonstrate p23 is implicated in prostate cancer cell motility and in acquisition of invasiveness capacity through the expression of specific genes known to participate in cancer progression. This may drive metastatic processes in vivo since analysis of prostate tumour biopsies revealed that high nuclear p23 significantly correlated with shorter survival times and with development of metastases in patients with lower grade tumours. We propose that increased p23 expression may allow cells to acquire a more aggressive phenotype, contributing to disease progression, and that p23 is a plausible secondary target in combination with HSP90 inhibition as a potential therapy for advanced prostate cancer.</jats:p>
Item Type: | Article |
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Uncontrolled Keywords: | p23; Androgen receptor; Chaperone; Prostate cancer; Metastasis; Heat shock protein 90 |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 09 Feb 2015 12:25 |
Last Modified: | 07 Aug 2024 19:33 |
URI: | http://repository.essex.ac.uk/id/eprint/12729 |