Zimmermann, E and Ängquist, LH and Mirza, SS and Zhao, JH and Chasman, DI and Fischer, K and Qi, Q and Smith, AV and Thinggaard, M and Jarczok, MN and Nalls, MA and Trompet, S and Timpson, NJ and Schmidt, B and Jackson, AU and Lyytikäinen, LP and Verweij, N and Mueller-Nurasyid, M and Vikström, M and Marques-Vidal, P and Wong, A and Meidtner, K and Middelberg, RP and Strawbridge, RJ and Christiansen, L and Kyvik, KO and Hamsten, A and Jääskeläinen, T and Tjønneland, A and Eriksson, JG and Whitfield, JB and Boeing, H and Hardy, R and Vollenweider, P and Leander, K and Peters, A and van der Harst, P and Kumari, M and Lehtimäki, T and Meirhaeghe, A and Tuomilehto, J and Jöckel, K-H and Ben-Shlomo, Y and Sattar, N and Baumeister, SE and Davey Smith, G and Casas, JP and Houston, DK and März, W and Christensen, K and Gudnason, V and Hu, FB and Metspalu, A and Ridker, PM and Wareham, NJ and Loos, RJF and Tiemeier, H and Sonestedt, E and Sørensen, TIA (2015) Is the adiposity-associated<i>FTO</i>gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obesity Reviews, 16 (4). pp. 327-340. DOI https://doi.org/10.1111/obr.12263
Zimmermann, E and Ängquist, LH and Mirza, SS and Zhao, JH and Chasman, DI and Fischer, K and Qi, Q and Smith, AV and Thinggaard, M and Jarczok, MN and Nalls, MA and Trompet, S and Timpson, NJ and Schmidt, B and Jackson, AU and Lyytikäinen, LP and Verweij, N and Mueller-Nurasyid, M and Vikström, M and Marques-Vidal, P and Wong, A and Meidtner, K and Middelberg, RP and Strawbridge, RJ and Christiansen, L and Kyvik, KO and Hamsten, A and Jääskeläinen, T and Tjønneland, A and Eriksson, JG and Whitfield, JB and Boeing, H and Hardy, R and Vollenweider, P and Leander, K and Peters, A and van der Harst, P and Kumari, M and Lehtimäki, T and Meirhaeghe, A and Tuomilehto, J and Jöckel, K-H and Ben-Shlomo, Y and Sattar, N and Baumeister, SE and Davey Smith, G and Casas, JP and Houston, DK and März, W and Christensen, K and Gudnason, V and Hu, FB and Metspalu, A and Ridker, PM and Wareham, NJ and Loos, RJF and Tiemeier, H and Sonestedt, E and Sørensen, TIA (2015) Is the adiposity-associated<i>FTO</i>gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obesity Reviews, 16 (4). pp. 327-340. DOI https://doi.org/10.1111/obr.12263
Zimmermann, E and Ängquist, LH and Mirza, SS and Zhao, JH and Chasman, DI and Fischer, K and Qi, Q and Smith, AV and Thinggaard, M and Jarczok, MN and Nalls, MA and Trompet, S and Timpson, NJ and Schmidt, B and Jackson, AU and Lyytikäinen, LP and Verweij, N and Mueller-Nurasyid, M and Vikström, M and Marques-Vidal, P and Wong, A and Meidtner, K and Middelberg, RP and Strawbridge, RJ and Christiansen, L and Kyvik, KO and Hamsten, A and Jääskeläinen, T and Tjønneland, A and Eriksson, JG and Whitfield, JB and Boeing, H and Hardy, R and Vollenweider, P and Leander, K and Peters, A and van der Harst, P and Kumari, M and Lehtimäki, T and Meirhaeghe, A and Tuomilehto, J and Jöckel, K-H and Ben-Shlomo, Y and Sattar, N and Baumeister, SE and Davey Smith, G and Casas, JP and Houston, DK and März, W and Christensen, K and Gudnason, V and Hu, FB and Metspalu, A and Ridker, PM and Wareham, NJ and Loos, RJF and Tiemeier, H and Sonestedt, E and Sørensen, TIA (2015) Is the adiposity-associated<i>FTO</i>gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obesity Reviews, 16 (4). pp. 327-340. DOI https://doi.org/10.1111/obr.12263
Abstract
Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n=169,551; 0.32kgm-2; 95% CI 0.28-0.32, P<1×10-32), WC (n=152,631; 0.76cm; 0.68-0.84, P<1×10-32) and FMI (n=48,192; 0.17kgm-2; 0.13-0.22, P=1.0×10-13). Cox proportional hazard regression analyses for mortality showed that the hazards ratio (HR) for the minor allele of the FTO SNPs was 1.02 (1.00-1.04, P=0.097), but the apparent excess risk was eliminated after adjustment for BMI and WC (HR: 1.00; 0.98-1.03, P=0.662) and for FMI (HR: 1.00; 0.96-1.04, P=0.932). In conclusion, this study does not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FTO; meta-analysis; mortality; obesity |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 15 May 2015 14:07 |
| Last Modified: | 18 Aug 2022 11:08 |
| URI: | http://repository.essex.ac.uk/id/eprint/13696 |