Yuan, C and Wang, J and Harrison, AP and Meng, X and Chen, D and Chen, M (2015) Genome-wide view of natural antisense transcripts in Arabidopsis thaliana. DNA Research, 22 (3). pp. 233-243. DOI https://doi.org/10.1093/dnares/dsv008
Yuan, C and Wang, J and Harrison, AP and Meng, X and Chen, D and Chen, M (2015) Genome-wide view of natural antisense transcripts in Arabidopsis thaliana. DNA Research, 22 (3). pp. 233-243. DOI https://doi.org/10.1093/dnares/dsv008
Yuan, C and Wang, J and Harrison, AP and Meng, X and Chen, D and Chen, M (2015) Genome-wide view of natural antisense transcripts in Arabidopsis thaliana. DNA Research, 22 (3). pp. 233-243. DOI https://doi.org/10.1093/dnares/dsv008
Abstract
Natural antisense transcripts (NATs) are endogenous transcripts that can form double-stranded RNA structures. Many protein-coding genes (PCs) and non-protein-coding genes (NPCs) tend to form cis-NATs and trans-NATs, respectively. In this work, we identified 4,080 cis-NATs and 2,491 trans-NATs genome-widely in Arabidopsis. Of these, 5,385 NAT-siRNAs were detected from the small RNA sequencing data. NAT-siRNAs are typically 21nt, and are processed by Dicer-like 1 (DCL1)/DCL2 and RDR6 and function in epigenetically activated situations, or 24nt, suggesting these are processed by DCL3 and RDR2 and function in environment stress. NAT-siRNAs are significantly derived from PC/PC pairs of trans-NATs and NPC/NPC pairs of cis-NATs. Furthermore, NAT pair genes typically have similar pattern of epigenetic status. Cis-NATs tend to be marked by euchromatic modifications, whereas trans-NATs tend to be marked by heterochromatic modifications.
Item Type: | Article |
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Uncontrolled Keywords: | Arabidopsis; Histones; RNA, Antisense; RNA, Small Interfering; DNA Methylation; Protein Processing, Post-Translational; Genome, Plant; Gene Regulatory Networks |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Mathematics, Statistics and Actuarial Science, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 10 Jul 2015 09:36 |
Last Modified: | 16 May 2024 16:17 |
URI: | http://repository.essex.ac.uk/id/eprint/14289 |
Available files
Filename: DNA Res-2015-Yuan-233-43.pdf
Licence: Creative Commons: Attribution 3.0