%PDF-1.6
%
272 0 obj
<>
endobj
260 0 obj
<>
endobj
259 0 obj
<>stream
Arbortext Advanced Print Publisher 10.0.1465/W Unicode
2015-09-25T02:03-07:00
2015-08-10T22:13:49+05:30
2015-09-25T02:03-07:00
application/pdf
doi:;
untitled
Acrobat Distiller 8.1.0 (Windows)
uuid:ad9b8fb1-df93-4b45-a76e-11f6aecae162
uuid:89a375e0-1dd2-11b2-0a00-15f6d8fef5ff
http://dx.doi.org/
2015-08-10
false
http://bmjopen.bmj.com
2015-08-10
true
http://bmjopen.bmj.com
endstream
endobj
273 0 obj
<>
endobj
184 0 obj
<>
endobj
256 0 obj
<>
endobj
258 0 obj
<>
endobj
538 0 obj
<>
endobj
539 0 obj
<>
endobj
57 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 204 0 R/Type/Page>>
endobj
84 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 205 0 R/Type/Page>>
endobj
90 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 206 0 R/Type/Page>>
endobj
102 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 207 0 R/Type/Page>>
endobj
113 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 208 0 R/Type/Page>>
endobj
540 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
541 0 obj
<>/ProcSet[/PDF/Text]>>/Type/Page>>
endobj
573 0 obj
[575 0 R 576 0 R 577 0 R 578 0 R 579 0 R 580 0 R 581 0 R]
endobj
574 0 obj
<>stream
BT
/T1_0 1 Tf
12 0 0 12 119.29999 724.99997 Tm
(service)Tj
-2.83299 1 Td
(Email alerting)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 728.99997 Tm
(box at the top right corner of the online article. )Tj
0 1 TD
(Receive free email alerts when new articles cite this article. Sign up i\
n the)Tj
ET
84 702 m
511 702 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
12 0 0 12 95.98444 663.99997 Tm
(Collections)Tj
3.00099 1 Td
(Topic)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 678 Tm
(Articles on similar topics can be found in the following collections )Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 290.16 648.99997 Tm
( \(147\))Tj
0 0 1 rg
-9.616 0 Td
(Smoking and tobacco)Tj
0 g
12.506 1 Td
( \(217\))Tj
0 0 1 rg
-12.506 0 Td
(Diabetes and Endocrinology)Tj
ET
84 635 m
511 635 l
0 0 m
S
BT
ET
BT
0 g
/T1_0 1 Tf
12 0 0 12 84 614 Tm
(Notes)Tj
ET
84 182 m
511 182 l
0 0 m
S
BT
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 143.99997 Tm
(http://group.bmj.com/group/rights-licensing/permissions)Tj
0 g
/T1_1 1 Tf
T*
(To request permissions go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 109.99997 Tm
(http://journals.bmj.com/cgi/reprintform)Tj
0 g
/T1_1 1 Tf
T*
(To order reprints go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 75.99997 Tm
(http://group.bmj.com/subscribe/)Tj
0 g
/T1_1 1 Tf
T*
(To subscribe to BMJ go to:)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 416.67187 780 Tm
(group.bmj.com)Tj
0 g
-17.62099 0 Td
( on September 25, 2015 - Published by )Tj
0 0 1 rg
-10.67097 0 Td
(http://bmjopen.bmj.com/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
570 0 obj
<>
endobj
547 0 obj
<>
endobj
575 0 obj
<>
endobj
576 0 obj
<>
endobj
577 0 obj
<>
endobj
578 0 obj
<>
endobj
579 0 obj
<>
endobj
580 0 obj
<>
endobj
581 0 obj
<>
endobj
588 0 obj
<>
endobj
587 0 obj
<>
endobj
586 0 obj
<>
endobj
585 0 obj
<>
endobj
584 0 obj
<>
endobj
583 0 obj
<>
endobj
582 0 obj
<>
endobj
568 0 obj
[589 0 R 590 0 R 591 0 R 592 0 R 593 0 R 594 0 R 595 0 R 596 0 R 597 0 R 598 0 R 599 0 R 600 0 R]
endobj
569 0 obj
<>stream
q
61.5 0 0 38.75 103.25 714.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
15 0 0 15 184 677.99988 Tm
(consortium)Tj
0 1 TD
(randomisation meta-analysis. The CARTA)Tj
T*
(a causal relationship from a Mendelian )Tj
20.28695 1.00001 Td
(for)Tj
-20.28695 0 Td
(increase in waist circumference: evidence )Tj
T*
(Heavier smoking may lead to a relative)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 503.99951 Tm
(Sattar)Tj
T*
(Romundstad, Thorkild I A S\370rensen, Marcus R Munaf\362 and Naveed )Tj
0 1.00001 TD
(Kaprio, Mika Kivimaki, Blair H Smith, Caroline Hayward, P\345l R)Tj
0 1 TD
(Hypp\366nen, Marjo-Riitta Jarvelin, Martin Preisig, Katja Borodulin, Jaa\
kko )Tj
T*
(Lawlor, Allan Linneberg, Ian Ford, J Wouter Jukema, Chris Power, Elina)Tj
0 1.00001 TD
(Jacqueline M Vink, Dorret I Boomsma, George Davey Smith, Debbie )Tj
0 1 TD
(Diana Kuh, Graham Watt, Johan G Eriksson, Peter H Whincup,)Tj
T*
(Martin A Kennedy, Ellen A Nohr, Lene Christiansen, Kirsten Ohm Kyvik, )Tj
T*
(Yoav Ben-Shlomo, Jessica Tyrrell, John Horwood, David M Fergusson,)Tj
0 1.00001 TD
(Padmanabhan, Andrew Wong, Christine Dalg\345rd, Lavinia Paternoster, )Tj
0 1 TD
(Lahti, Aarno Palotie, Katri R\344ikk\366nen, Alex McConnachie, Sandosh)Tj
T*
(L Treur, Gonneke Willemsen, Caroline Dale, S Goya Wannamethee, Jari )Tj
0 1.00001 TD
(Lise Lotte N Husemoen, Tea Skaaby, Tarun Veer Singh Ahluwalia, Jorien)Tj
0 1 TD
(Pedro Marques-Vidal, Marika Kaakinen, Alana Cavadino, Iris Postmus, )Tj
T*
(Riccardo Marioni, Meena Kumari, Tellervo Korhonen, Satu M\344nnist\366,)Tj
0 1.00001 TD
(Bj\370rn Olav \305svold, Maiken Elvestad Gabrielsen, Archie Campbell, )Tj
0 1 TD
(Richard W Morris, Amy E Taylor, Meg E Fluharty, Johan H Bj\370rngaard,)Tj
ET
BT
/T1_1 1 Tf
12 0 0 12 184 467.99997 Tm
(doi: 10.1136/bmjopen-2015-008808)Tj
10 0 0 10 234.02002 480 Tm
(2015 5: )Tj
/T1_2 1 Tf
-5.002 0 Td
(BMJ Open\240)Tj
ET
84 454 m
511 454 l
0 0 m
S
BT
ET
BT
/T1_1 1 Tf
10 0 0 10 394.60901 419.99997 Tm
( )Tj
0 0 1 rg
/T1_0 1 Tf
-21.0609 0 Td
(http://bmjopen.bmj.com/content/5/8/e008808)Tj
0 g
/T1_1 1 Tf
T*
(Updated information and services can be found at: )Tj
ET
84 406 m
511 406 l
0 0 m
S
BT
ET
BT
/T1_2 1 Tf
10 0 0 10 184 378 Tm
(These include:)Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 125.31604 345.99997 Tm
(Material)Tj
-3.16699 1 Td
(Supplementary)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 247.34995 319.99988 Tm
( )Tj
0 0 1 rg
/T1_0 1 Tf
-6.33499 0 Td
(808.DC2.html)Tj
T*
(http://bmjopen.bmj.com/content/suppl/2015/08/12/bmjopen-2015-008)Tj
0 g
/T1_1 1 Tf
6.33499 1.00001 Td
( )Tj
0 0 1 rg
/T1_0 1 Tf
-6.33499 0 Td
(808.DC1.html)Tj
T*
(http://bmjopen.bmj.com/content/suppl/2015/08/11/bmjopen-2015-008)Tj
0 g
/T1_1 1 Tf
T*
(Supplementary material can be found at: )Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 99.30817 300 Tm
(References)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 421.84915 291.99997 Tm
( )Tj
0 0 1 rg
-2.72401 0 Td
(#BIBL)Tj
/T1_0 1 Tf
-21.06091 0 Td
(http://bmjopen.bmj.com/content/5/8/e008808)Tj
0 g
/T1_1 1 Tf
T*
(This article cites 30 articles, 10 of which you can access for free at: \
)Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 87.96826 272 Tm
(Open Access)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
10 0 0 10 184 233.99988 Tm
(http://creativecommons.org/licenses/by/4.0/)Tj
0 g
T*
(use, provided the original work is properly cited. See: )Tj
0 1.00001 TD
(others to distribute, remix, adapt and build upon this work, for commerc\
ial)Tj
0 1 TD
(the Creative Commons Attribution \(CC BY 4.0\) license, which permits )Tj
T*
(This is an Open Access article distributed in accordance with the terms \
of)Tj
ET
84 182 m
511 182 l
0 0 m
S
BT
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 143.99997 Tm
(http://group.bmj.com/group/rights-licensing/permissions)Tj
0 g
/T1_1 1 Tf
T*
(To request permissions go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 109.99997 Tm
(http://journals.bmj.com/cgi/reprintform)Tj
0 g
/T1_1 1 Tf
T*
(To order reprints go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 75.99997 Tm
(http://group.bmj.com/subscribe/)Tj
0 g
/T1_1 1 Tf
T*
(To subscribe to BMJ go to:)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 416.67187 780 Tm
(group.bmj.com)Tj
0 g
-17.62099 0 Td
( on September 25, 2015 - Published by )Tj
0 0 1 rg
-10.67097 0 Td
(http://bmjopen.bmj.com/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
572 0 obj
<>/Filter/FlateDecode/Height 155/Length 8359/Name/X/Subtype/Image/Type/XObject/Width 246>>stream
HLTa0 EjDUۋPmmۤI[Ԥi#X)Mڤ)>&TEk""0cܟ9z30?r8^k[E"$"Ĵp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-".jpt]mXp8PZ탟wA\ATZWC)túD#ĝA NycZ=%$Gd]ujmo#FB3l"B4W,qR°0 &&D:,İ(%s1o~X8}zhttȤI&Nb6{K:~*m I%$|``px;6twoAt[g-*SF Qb%K]0~䑩0S`;6ݹsm7> oN!d8]'?ޚ!`A1 CbF8kS`Zϸ.XPRr{4bI /(Xf0A*/VTTUUeA\%sl11ݻO[-Zƿ^ܹ0v\[#|dV#,*3^K/ݿxq$ڰށW-lĎ
><|"
%KJ.SE?t~wߝղg'>H>Dc}}xcKVu$r8F=w==}KD];= PwzTu{T`_ Ƙ n|ϞӨ8II_@8=ex^}uSO=êG}s`|F6y#)'CIBIE*K G||d+`*0[&Vnh\Q/ECr
7;]V
G *\HdP|Dg18M!+ʕ+KKKą]!M֘4nOA)Zf[GG/ƌaa&Z6/.,<'$^JG8~ֺ:C'Ѐɓ"#
==NIrGL&sqq}τsKT0wLLfH=±wΜp馃3qsnc#aժխS
asbv+oxbs"Ippnҝ;O ;p6n\${4s9-3?
+[Ӱ04?),AP\ںl",fl6x'A/IN>
;Gq(5b߁"@g!<־r=lexYCKi6uĵAf̘Y'[ZlxX|>z]jdJ9s"H|ϋn۶81q'8cF8iBТ`"a"lpjP}9</ڼd*B%xǎe~~|?֮3/G